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Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study

By Michael Keane, BMBS, FANZCA and Shashikanth Manikappa, MD, DNB, FANZCA
February 21, 2019

Patient safety requires a well-informed debate about the rationale of large, randomized controlled trials (RCTs) and whether, by their very nature, they can adequately consider the unique physiology of every individual patient. 

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WAKE-UP Time for Thrombolysis in Acute Stroke?


By Martina McGrath, MD
October 30, 2018

MRI thrombolysis for stroke of unknown time of onset

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Prior studies have suggested a particular pattern may be seen on an MRI of the brain in the early hours following stroke onset; a visible ischemic lesion on diffusion-weighted imaging along with the lack of a hyperintense signal in the same area on fluid-attenuated inversion recovery (FLAIR). The benefit of aggressive stroke intervention in patients with the combination of unknown time of symptom onset and this particular signal mismatch on MRI brain scans is unknown. Continue reading “WAKE-UP Time for Thrombolysis in Acute Stroke?”

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By Olivier Lucar
October 16, 2018

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By Connor Emdin
September 26, 2018

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Restrictive versus Liberal Fluid Therapy in Abdominal Surgery

By Connor Emdin
August 28, 2018

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Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?

By Martina McGrath, MD
August 8, 2018

It is estimated that 1 in every 7.5 people in the US will die of sudden cardiac death.Zilco SL Sportz Carriage Driving Harness Set Survival following out-of-hospital cardiac arrest has increased in recent years, from 10.2% in 2006, to 12.4% in 2015.1 However, only 9% of those surviving to hospital discharge were classified as having good functional status. Therefore, significant long-term neurologic impairment is a common outcome of cardiac arrest. Continue reading “Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?”

Cervical Cancer Screening Using HPV Testing Alone: Are We There Yet?

Billy Cook 14.5” barrel saddle

By Martina McGrath, MD
July 18, 2018

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3206 - CASCO modello MATT KEP ITALIA utbfia2936-Riding Hats

Item specifics

New with tags: A brand-new, unused, unworn and undamaged item in the original packaging (such as the original box ... Read moreabout the condition
Marca: Kep Italia
MPN: 3206

Dulaglutide in Type 2 Diabetes: Do GLP-1 agonists delay progression of diabetic nephropathy?

Circle Y Powder River All-Around Trail Saddle

By Connor Emdin
June 27, 2018

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Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infection: Is It Safe?


By Martina McGrath, MD
June 5, 2018

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Seaguar FXR Flugoldcarbon Leader Line 100m Size 7 25lb (9337)

By Lea Borgi, MD
May 16, 2018

NUEVO 2018 Ryobi Spiritual 500-800 spinning reel Carrete en aguas heladasShimano CERAMIC Super Tune bearings TORIUM 50PRO'S FACTORY INCUBATOR DROP 75 MAT FROG color NIP Continue reading “Does Menu Labeling Lead to Healthier Food Choices?”